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In the model, trovafloxacin elicited vascular and hepatocellular toxicity associated with pro-inflammatory cytokine release already at clinically relevant concentrations, whereas levofloxacin did not provoke tissue injury

Reported side effects are minimal, with most users tolerating MOTS-c well

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2.6 Quality assessment Methodological quality was assessed using the Critical Appraisal Skills Programme (CASP) checklists for all study types [24]